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Publications
- Taguchi Optimization of Additively Manufactured PEKK and Silicon Nitride Loaded PEKK for Medical Device Applications
- A Novel Antipathogenic Agent for Nonwoven Fabric
- Transforaminal lumbar interbody fusion with a silicon nitride cage demonstrates early radiographic fusion
- Comprehensive in vitro comparison of cellular and osteogenic response to alternative biomaterials for spinal implants
- Enhanced Bioactivity and Bacteriostasis of PEEK Polymers Through Incorporation of Silicon Nitride Particles
- An Assessment of the Inherent Antimicrobial Resistance of Biomaterials Utilized in Spinal Fusion Surgery
- Differential Bacterial Expression on Silicon Nitride, PEEK, and Titanium Surfaces
- Silicon Nitride Bioceramics Induce Chemically Driven Lysis in Porphyromonas Gingivalis
- Patent Application US20130302509: Antibacterial Biomedical Implants and Associated Materials, Apparatus, and Methods
- In Vivo Bone Formation and Bacterial Infection Between Silicon Nitride Ceramic, PEEK, and Titanium
- Decreased Bacteria Activity on Si3N4 Surfaces Compared with PEEK or Titanium
- Anti-Infective and Osteointegration Properties of Silicon Nitride, Poly (Ether Ether Ketone), and Titanium Implants
- Antipathogenic Devices and Methods Thereof, US Pat. Appl. 2020 0079651
- Metabolic Machinery Encrypted in the Raman Spectrum of Influenza A Virus-Inoculated Mammalian Cells
- In situ Molecular Vibration Insights into the Antibacterial Behavior of Silicon Nitride Bioceramic Versus Gram-Negative Escherichia coli
- Label-Free SERS Discrimination and In Situ Analysis of Life Cycle in Escherichia coli and Staphylococcus epidermidis
- In vitro Antibacterial Activity of Oxide and Non-Oxide Bioceramics for Arthroplastic Devices: I. In situ Time-Lapse Raman Spectroscopy
- A Spontaneous Solid-State NO Donor to Fight Antibiotic Resistant Bacteria
- Monitoring Metabolic Reactions in Staphylococcus epidermidis Exposed to Silicon Nitride using in situ Time-lapse Raman Spectroscopy
- Treatment of lumbar discitis using silicon nitride spinal spacers: A case series and literature review
- Surface Topography of Silicon Nitride Affects Antimicrobial and Osseosintegrative Properties of Tibial Implants in a Murine Model
- Rapid Inactivation of SARS-CoV-2 by Silicon Nitride, Copper, and Aluminum Nitride
- Instantaneous “Catch-and-Kill” Inactivation of SARS-CoV-2 by Nitride Ceramics
- Antipathogenic Compositions and Methods Thereof, Int. Pat. Appl. WO 2020/051004
- Ceramics and Ceramic Coatings in Orthopaedics
- Bioceramics for Hip Joints: The Physical Chemistry Viewpoint
- Non-Oxide Ceramics in Arthroplasty: The Case for Silicon Nitride as a Novel Biomaterial
- Orthopedic Applications of Silicon Nitride Ceramics
- Antifungal Activity of PMMA/Si3N4 Composites Against Candida Albicans
- A Potent Solid-State Bioceramic Inactivator of ssRNA Viruses
- Activity and Mechanism of Action of the Bioceramic Silicon Nitride as an Environmentally Friendly Alternative for the Control of the Grapevine Downy Mildew Pathogen Plasmopara viticola
- Antimicrobial Nitric Oxide Releasing Compounds and Scaffolds
- Silicon Nitride Inactivates SARS-CoV-2 in vitro
- Methods for Threading Sinterable Materials and Related Apparatus and Systems, US Pat. 9,399,309 (2016)
- Coated Implants and Related Methods US Pat. 9,051,639 (2015)
- Surface Toughness of Silicon Nitride Bioceramics: II, Comparison with Commercial Oxide Materials
- Surface Toughness of Silicon Nitride Bioceramics: I, Raman Spectroscopy-Assisted Micromechanics
- Surface Modulation of Silicon Nitride Ceramics for Orthopaedic Applications
- Effect of pH and Monovalent Cations on the Raman Spectrum of Water: Basics Revisited and Application to Measure Concentration Gradients at Water/Solid Interface in Si3N4 Biomaterial
- Point-Defect Populations as Induced by Cation/Anion Substitution in β-Si3N4 Lattice: A Cathodoluminescence Study
- Differential Effects of Hydrothermal Ageing on the Surface Fracture Toughness of Ceramics
- Debunking the Myth that Ceramics are Bioinert: Comparison of Alumina versus Silicon Nitride
- Surface Modulation of Silicon Nitride Ceramics for Orthopaedic Applications
- Bioceramics are not Bioinert
- Robocasting of Silicon Nitride with Controllable Shape and Architecture for Biomedical Applications
- Alumina-Zirconia Ceramic Implants and Related Materials, Apparatus, and Methods US Pat. 9,353,010 (2016)
- The Scientific Rationale for Using Silicon Nitride in Biomedical Implants
- Charge-Compensating Dopant Stabilized Alumina-Zirconia Ceramic Materials and Related Materials, Apparatus, and Methods US Pat. 9,353,012 (2016)
- Processing and Characterization of Silicon Nitride Bioceramics
- Metal Ions Contribute to the Material Instability of Zirconia Toughened Alumina
- Silicon Nitride - A Ceramic Surgical Implant Material
- Surface Functionalization of Polyethylene by Silicon Nitride Laser Cladding
- Silicon Nitride Laser Cladding: A Feasible Technique to Improve the Biological Response of Zirconia
- Ceramic and/or Glass Materials and Related Methods US Pat. 9,925,295 (2018)
- Raman Spectroscopy of Biomedical Polyethylenes
- Silicon Nitride Bioceramics in Healthcare
- Bioceramics: From Clinic to Concept
- Surface Functionalization of PEEK with Silicon Nitride
- Surface Chemistry of Bioceramics: The Missing Key
- In Vitro Comparison of Bioactive Silicon Nitride Laser Claddings on Different Substrates
- Bioactive Silicon Nitride: A New Therapeutic Material for Osteoarthropathy
- The Novel Use of Acoustic Emission Monitoring during Proof-Testing of Ceramic Spinal Implants
- Radiographic Follow-up of Transforaminal Lumbar Fusion with Silicon Nitride Spacers: A Case Report of Two Patients
- In Situ Spectroscopic Screening of Osteosarcoma Living Cells on Stoichiometry-Modulated Silicon Nitride Bioceramic Surfaces
- Silicon Nitride: A Synthetic Mineral for Vertebrate Biology
- The SNAP Trial: A Double Blind Multi-Center Randomized Controlled Trial of a Silicon Nitride Versus a PEEK Cage in Transforaminal Lumbar Interbody Fusion in Patients with Symptomatic Degenerative Lumbar Disc Disorders: Study Protocol
- The CASCADE Trial: Effectiveness of Ceramic versus PEEK Cages for Anterior Cervical Discectomy with Interbody Fusion; Protocol of a Blinded Randomized Controlled Trial
- Radiolucent Bone Graft Eur. Pat. EP 2,055,267 (2013)
- Enhanced Osteoblast Proliferation and Hydroxyapatite Formation on Surface Modulated Silicon Nitride
- Osteoinductive Properties of Silicon Nitride, Alumina, and Titanium
- Porous Silicon Nitride Spacers versus PEEK Cages for Anterior Cervical Discectomy and Fusion: Clinical and Radiological Results of a Single-Blinded Randomized Controlled Trial
- The Effect of Cervical Interbody Cage Morphology, Material Composition, and Bone Density on Subsidence Risk
- Bacteriostatic Behaviour of Biomaterials Utilised in Spinal Fusion Surgery
- The Antimicrobial Resistance of Oxide and Non-Oxide Ceramics
- Improved Bioactivity and Bacteriostasis of PEEK Polymers by Addition of Silicon Nitride Particles
- Bacteriostatic Behavior of Surface-Modulated Silicon Nitride in Comparison to Polyetheretherketone and Titanium
- Human Osteoblasts Grow Transitional Si/N Apatite in Quickly Osteointegrated Si3N4 Cervical Insert
- Silicon nitride surface chemistry: a potent regulator of mesenchymal progenitor cell activity in bone formation
- Development of a SiYAlON Glaze for Improved Osteoconductivity of Implantable Medical Devices
- Surface Chemistry of a Silicon Nitride Bioceramic Enhances Spinal Fusion: A Case Study
- Biomedical Implant Inserters and Related Apparatus, Systems, and Methods
- Thin-Walled Implant Structures and Related Methods
- Osseointegration and Biocompatibility Evaluation of Silicon Nitride Composite Using Ovine Distal Femoral Epiphyseal Insertion and Rabbit Paravertebral Muscle Implantation Models
- Bioglass Functionalization of Laser-Patterned Bioceramic Surfaces and their Enhanced Bioactivity
- Understanding Silicon Nitride’s Biological Properties: From Inert to Bioactive Ceramic
- Biological Response of Human Osteosarcoma Cells to Si3N4-Doped Bioglasses
- Comparison of Polyetheretherketone versus Silicon Nitride Intervertebral Spinal Spacers in a Caprine Model
- A Single Center Retrospective Clinical Evaluation of Anterior Cervical Discec-tomy and Fusion Comparing Allograft Spacers to Silicon Nitride Cages
- Incorporating Si3N4 into PEEK to Produce Antibacterial, Osteoconductive, and Radiolucent Spinal Implants
- Upregulation of Osteoblastic Activity by Si-Y-N-O Phase Chemistry
- Accelerated Cervical Fusion of Silicon Nitride versus PEEK Spacers: A Comparative Clinical Study
- Wear and Surface Degradation of Commercial ZTA Femoral Heads under Boundary Lubrication Conditions
- On the Molecular Interaction between Femoral Heads and Polyethylene Liners in Artificial Hip Joints: Phenomenology and Molecular Scale Phenomena
- Reconciling in vivo and in vitro Kinetics of the Polymorphic Transformation in Zirconia-Toughened Alumina for Hip Joints: II. Theory
- Reconciling in vivo and in vitro Kinetics of the Polymorphic Transformation in Zirconia-Toughened Alumina for Hip Joints: I. Phenomenology
- Chemistry-Driven Structural Alterations in Short-Term Retrieved Ceramic-on-Metal Hip Implants: Evidence for in vivo Incompatibility between Ceramic and Metal Counterparts
- Composite Metallic-Ceramic Implants and Related Methods
- Reconciling in vivo and in vitro Kinetics of the Polymorphic Transformation in Zirconia-Toughened Alumina for Hip Joints: III. Molecular Scale Mechanisms
- Silicon Nitride: A Bioceramic with a Gift
- Data-Driven Innovations in Joint Replacement: Do Ceramic Femoral Heads Contribute to Polyethylene Oxidation?
- Comparative Wear Performance of Ceramic-on-Ceramic Bearings under Non-Standard Hip Simulation
- Transition Metal Ions Accelerate Polymorphic Phase Transformation in Zirconia-Toughened Alumina Artificial Hip Joints: An in vitro Study
- Influence of Oxide versus Non-Oxide Femoral Heads on the Oxidation of Polyethylene Acetabular Liners
- In situ Monitoring of Osteosarcoma Cells on Surface-Modulated Silicon Nitride and Titanium Biomaterials
- In Toto Microscopic Scanning of ZTA Femoral Head Retrievals using CAD-Assisted Confocal Raman Spectroscopy
- Surface Pre-Oxidation Improves the Wear Performance of Si3N4 Against UHMWPE
- Mechanisms Induced by Transition Metal Contaminants and their Effect on the Hydrothermal Stability of Zirconia-Containing Bioceramics: An XPS Study
- Degradation Phenomena Occurring in the Conical Taper of a Short-Term Retrieved ZTA Femoral Head: A Case Study
- Bioceramics are Not Bioinert: The Role of Oxide and Non-Oxide Bioceramics on the Oxidation of UHMWPE Components in Artificial Joints
- Transition Metals Increase Hydrothermal Stability of Yttria-Tetragonal Zirconia Polycrystals (3Y-TZP)
- In vitro Antibacterial Activity of Oxide and Non-Oxide Bioceramics for Arthro-plastic Devices: II. In situ Time-Lapse Fourier Transform Infrared Spectroscopy
- Oxide Ceramic Femoral Heads Contribute to the Oxidation of Polyethylene Liners in Artificial Hip Joints
- Oxide Ceramic Femoral Heads Contribute to Polyethylene Liner Degradation
- Tensor-Resolved Raman Spectroscopic Analysis of Wear-Induced Residual Stress Fields in Long-Term Alumina Hip-Joint Retrievals
- In Vitro versus In Vivo Phase Instability of Zirconia-Toughened Alumina Femoral Heads: A Critical Comparative Assessment
- Wear Simulation of Ceramic-on-Crosslinked Polyethylene Hip Prostheses: A New Non-Oxide Silicon Nitride versus the Gold Standard Composite Oxide Ceramic Femoral Heads
- Fretting Corrosion of Si3N4 vs CoCrMo Femoral Heads on Ti-6Al-V Trunnions
- Burst Strength of BIOLOX®delta Femoral Heads and its Dependence on Low-Temperature Environmental Degradation
- Method for Improving the Wear Performance of Ceramic-Polyethylene or Ceramic-Ceramic Articulation Couples Utilized in Orthopaedic Joint Prostheses
- Raman and X-Ray Photoelectron Spectroscopic Characterizations of Thermal Stability of 3 mol% Yttria Stabilized Zirconia Ceramics
Case Studies
- Clinical Report: Management of Two Patients Using a Novel Ceramic Implant
- Clinical Perspective: Laminectomy, Decompression and Fusion with Facet Bolts
- A Surgeon's Perspective: Laminectomy with Facet Fusion
- Clinical Perspective: Decompression and Fusion with the Valeo TL Transforaminal Interbody Fusion Device
- Treatment of Adjacent Level Disease Using Ceramic Silicon Nitride Implants in a Heavy Smoking, Morbidly Obese Patient
- Multi-level Posterior Lumbar Interbody Fusion Using Ceramic Silicon Nitride & Allograft Bone in a Single Patient
- Multi-level Oblique Lumbar Interbody Fusion Using Ceramic Silicon Nitride
- Two-level ACDF Using Silicon Nitride Implants in a Case of Severe Neck and Arm Pain
- Two-level ACDF Using Silicon Nitride Implants in a Case of Quickly Progressing Loss of Deltoid Strength
- Single-level ACDF Using Silicon Nitride Interbody
- Retrospective Radiographic Review of PEEK and Silicon Nitride Spinal Implants in the Same Patient
- Radiographic Follow-up of Transforaminal Lumbar Fusion with Silicon Nitride Spacers: A Case Report of Two Patients
Research Literature
- Biomaterial Comparison Overview
- Technology Update: Stiffness and Imaging Characteristics
- SINTX Scientific Publication Portfolio
- Mechanical Properties and Osseointegration of a Load Bearing Bioactive Bone Graft
- Biocompatibility features of silicon nitride ceramics and possible application for osteosynthesis systems
- Reduced Bacteria Colonization and Increased Bone Formation on Si3N4 Spinal Implants: An Evaluation of Bacterial Colonization on Existing Implant Materials
- Increased Bone Attachment to Silicon Nitride (Si3N4) Materials Used in Interbody Fusion Cages (IBF) Compared to Polyetheretherketone (PEEK) and Titanium (Ti) Materials – An In vivo Study
- Decreased Bacterial Biofilm Formation and Function Associated with Silicon Nitride (Si3N4) Materials used in Interbody Fusion Cages (IBF) Compared to Titanium and Polyetheretherketone (PEEK)
- Just the Facts - Silicon Nitride